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By whole-hippocampus RNA-seq they observed that the knockout of TLX upregulates 1272 genes, compared to wild-type, of which 1096 are implicated in cell chemotaxis ( Cxcr2 , IL17RA , Cxcl10 , Fgf2 , Cxcl5 , Ccl9 , Ccr1 , Cxcl13 ) and 176 are in common with genes increased in wild-type mice injected with IL-1β into the hippocampus and are implicated in cell response to cytokine stimulus ( Nfkbia , IL6 , Cxcl1 , Ccl2 )

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