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Although all pharmacological methods have drawbacks, acetaminophen is not considered to be highly effective for pain relief

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Namely, a major index of protein oxidation is the introduction of carbonyl groups to the protein, and the dipole moment of the C=O bond leads to rearrangement of the protein conformation to allow the polarity of the carbonyl bonds to be close to the surface of the protein and in contact with the cell’s various aqueous phases