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DRD2 agonists, among which cabergoline is the most effective and best tolerated, are first-line therapy for prolactinomas as they are effective in controlling clinical symptoms, PRL levels, and tumor volume ( Figure 1 Somatostatin binds to a family of G-proteins coupled receptors (SSTR1-5), among which subtypes 2 and 5 are expressed at high density in most GH-secreting pituitary tumors ( 2+ and K + channels, all these events being involved in the reduction of hormone secretion [reviewed in Ref